Malegra 120 mg is a promising generic drug produced by Sunrise Remedies for the treatment of erectile dysfunction. Men who have impotence use it on as needed basis. The recommended dosage of Malegra is 120mg. The effect of this drug lasts for 4 -6 hours. Malegra 120 brand is to be taken one hour before sexual intercourse. It is advisable to drink a glass of water while consuming. Also, Malegra 120 should not be taken with alcohol or fatty meals. The available dosage form of Malegra are pills and oral jelly. If you have liver or kidney diseases, you should not take erectile dysfunction drugs. In addition, the drug may interact with nitrates and isosorbides. . The drug is not suitable for women and children. There are some side effects as a headache, gastric disturbances and nausea have been reported with Malegra 120. But these effects are mild and last for a few hours .
About Sunrise Remedies
Sunrise Remedies is a pharmaceutical company involved in making and supplying Herbal Remedies, Ayurvedic Preparations, and Cosmetics. Today, it is one of the new pharma companies in India. Also, it has a professionally directed team of highly qualified managers. This benefits in dealing with the manufacturing requests of pharmaceutical formulations in many dosages . Sunrise Remedies is already a US FDA-approved institution. In 1993, Sunrise Remedies was constructed by Mr. Jaman Malaviya and Mr. Mansukh Dhanani.
Sunrise remedies is an expert in the industry of Erectile Dysfunction products and JESIBI cream (back pain relief). It introduced many services as the development of products for active marketers. Recently it has many plans for the development of new drugs in neuropsychiatry and presenting new products in OTC. . Now, Sunrise Remedies drugs are found in many prescriptions. Also, it has been nominated for many medical advancements in several fields as ordinary medical fields and breakthroughs of medicine. Recently Sunrise Remedies was nominated for a prize for its product (Super P-Force) which was introduced in 2010 .
In 2009, there was an inspection of one of Sunrise manufacturing facilities which are located in New Jersey. The inspection found many violations of the Current Good Manufacturing Practice (CGMP) regulations. Also, there was adulteration within the meaning of section 501 of the Federal Food, Drug, and Cosmetic Act including the methods used in manufacturing the drug products, packing, processing, and holding. In addition, there was the manufacturing of many prescription drugs without approved applications. The facility also does not have control records and master production which are important in justifying variation in the components amount for dosage form preparation. For example, some of the products were made with excess amounts of active pharmaceutical ingredients. The facility failed to justify scientifically this excess in API. Based on the inspection, the institution does not have appropriate written measures for process control and production designed to emphasize that drug products have the quality, strength, identity, and purity that they claimed to have.
Scientific Studies on Sildenafil Citrate
In the study by H. George Nurnberg et al. titled “Efficacy of Sildenafil Citrate for the Treatment of Erectile Dysfunction in Men Taking Serotonin Reuptake Inhibitors” the goal was to value the effect of Sildenafil citrate in the treatment of erection problems in patients taking antidepressants (serotonin-reuptake-inhibitor). This study is a sub-analysis of information about placebo controlled, double blinded trials which lasted for 12-26 weeks. Patients were taking sildenafil (5-200 mg/day) or placebo and antidepressants(serotonin-reuptake-inhibitor). Results were dependent on questions about the ability to achieve and maintain an erection, ejaculation frequency, and sexual desire. There was an improvement in the ability to maintain erection and ejaculation frequency in patients taking sildenafil and antidepressants (serotonin-reuptake-inhibitor) than patients taking a placebo. In brief, we can conclude that there is an improvement in erectile dysfunction in patients taking sildenafil with antidepressants (serotonin-reuptake-inhibitor) .
Another study titled “Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents* a randomized controlled trial” by Thomas G. Pickering et al. (2004) is worth mentioning. The goal of this study was to value the effect of sildenafil citrate in treatment erectile dysfunction in 568 patients taking many antihypertensive drugs. These patients were taking sildenafil or placebo randomly for six weeks. But in the following six weeks, all patients took sildenafil. The results were dependent on questions about frequency of erection and penetration, and improvement in intercourse. After six weeks, there was an improvement in erection and intercourse in patients taking sildenafil than those who are taking a placebo. At week 12, all patients had an improvement in intercourse and erection. In brief, we can say that sildenafil is effective in the treatment of erectile dysfunction in patients taking medications for hypertension .
Also, there is a related study named “Ocular Safety in Patients Using Sildenafil Citrate Therapy for Erectile Dysfunction” by Alan Laties MD, and Ira Sharlip MD (2006). The goal of this study was to evaluate effects of sildenafil on visual function. Sildenafil citrate is a potent inhibitor of phosphodiesterase type 5, but it is a very weak inhibitor of phosphodiesterase type 6 which presents in photoreceptors of rod and cone. Several visual symptoms as blurred vision, increased sensitivity to light, and colored vision has been noticed in patients taking sildenafil. They are likely to occur if a patient is consuming higher doses. But eventually, visual function studies of visual function in people with good health and patients with ocular diseases found that sildenafil has no effect on ocular circulation, visual fields, retina, and acuity of vision .
Description and Mechanism of Action of Sildenafil Citrate
The physiology of erection is that nitric oxide activates the enzyme guanylate cyclase which causes an increase in cyclic guanosine monophosphate (cGMP). This enzyme causes erection by smoothing muscles of corpus cavernosum and allowing blood flow to the penis. Sildenafil is a potent inhibitor of phosphodiesterase type 5 (PDE5), which breaks down cGMP. In response to sexual stimulation, sildenafil causes an increase in cGMP resulting in relaxation of smooth muscle and flow of blood in the corpus cavernosum. Sildenafil does not work without sexual stimulation .
Effects of Sildenafil Citrate
Malegra120 contains sildenafil citrate which inhibits PDE-5. So, it causes full erection by causing a smooth in muscles in corps cavernosum and allows blood flow into the penis. Patients have noticed an improvement in erection and sexual intercourse. Now they enjoy sex with their partners .
Recommended Doses and Duration of Therapy
The recommended dosage of Malegra is 120mg.You should take the drug one hour before sexual intercourse. It is advisable to drink a glass of water. Also, you should not take the drug with alcohol or fatty meals. If you have liver or kidney diseases, you should not take erectile dysfunction. The drug may interact with nitrates and isosorbides . The drug is not suitable for women and children. The effect of this medication lasts up to 4 -6 hours .
Side Effects and Warnings
There are some side effects as a headache, gastric disturbances, and nausea that have been reported with Malegra 120. But these effects are mild and last for a few hours. In rare cases, chest pain, breath shortness, and painful erection may occur. Malegra 120 is not suitable for men suffering from arrhythmia, stroke, and myocardial infarction .
As for Malegra 120, it is not recommended to be taken with nitrates and isosorbide, as these drugs may interfere with the effectiveness of the product. The drug is not suitable for women and children. Also, diabetic patients should not use it .
Malegra 120mg has a good reputation on the web. Many customers talk about its effectiveness in treating erectile dysfunction. They said “it makes impossible possible” and “works great”.
Based on the reviews, customers said that before the treatment they were not able to achieve erection and thought it was impossible for them to make love anymore. But after the treatment, they can fight erectile dysfunction and regain confidence. In addition, they see that the price is affordable, enabling them to buy more of the product. However, there was a customer who said that he had nausea after first use but he now feels good.
Price, Available Forms, and Dosage
The price of Malegra 120mg is $54 for 10 pills. Thesiltratestore.com offers free shipping to any country including USA, UK, Australia and Canada on orders above $ 100. The available dosage form of Malegra is tablet and oral jelly. The recommended dose is 120 mg tablet in a day. You should take the drug one hour before sexual intercourse. The effect of Malegra 120 lasts for 4 -6 hours
Conclusion and Rating
The effectiveness of Malegra 120 mg in treatment erectile dysfunction is incredible. However, it has serious side effects as a headache, nausea, and gastric disturbances. Also,nitrates and isosorbide may interfere with the effectiveness of the product. Based on online reviews, the brand has a good reputation. Customers seem satisfied with the results, and now they can enjoy sex with their partners easily. However, there was a customer who said that he had nausea after first use but he now feels good. Malegra contains sildenafil citrate which causes a smooth in muscles in corps cavernosum and allows blood flow into the penis. So, it is effective in the treatment of erection problems. But as for my rating, I can rate it with 3 points out of 5 due to the poor credibility of its manufacturer.
Malegra 120 Wiki Facts
- Brand: Malegra 120
- Active Ingredient: Sildenafil Citrate
- Treatment: Erectile Dysfunction
- Manufacturer: Sunrise Remedies Pvt. Ltd.
- Country of Manufacture: India
- Availability: USA, UK, EU
- Malegra 120: Treatment for Erectile Dysfunction. Retrieved from: https://usrushed.com/drug-safety-info
- Malegra Contraindications. Retrieved from: https://usrushed.com/malegra-120
- Sunrise Remedies Overview. Retrieved from: http://sunriseremedies.in/
- Sunrise Remedies Services and Products. Retrieved from: http://sunriseremedies.in/about-us.html
- Sunrise Remedies Nominations. Retrieved from: https://www.puretablets.com/blog/sunrise-remedies-pvt-ltd-a-leading-future/
- Nurnberg, H. George, et al. “Efficacy of sildenafil citrate for the treatment of erectile dysfunction in men taking serotonin reuptake inhibitors.” American Journal of Psychiatry 158.11 (2001): 1926-1928. Available from: http://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.158.11.1926
- Pickering, Thomas G., et al. “Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents* A randomized controlled trial.” American journal of hypertension 17.12 (2004): 1135-1142. Available from: http://ajh.oxfordjournals.org/content/17/12/1135.short
- Laties, Alan, and Ira Sharlip. “Ocular safety in patients using sildenafil citrate therapy for erectile dysfunction.” The journal of sexual medicine 3.1 (2006): 12-27. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1743-6109.2005.00194.x/full
- Sildenafil: Drug Bank. Retrieved from: https://www.drugbank.ca/drugs/DB00203
- Effects of ‘Sildenafil Citrate’. Retrieved from: https://www.performanceinsiders.com/malegra-100.html
- Side effects and Warnings. Retrieved from: http://thesiltratestore.com/malegra-120
- Drug Interactions: The Kamagra Store. Retrieved from: http://thekamagrastore.info/malegra-120-sildenafil-citrate-120mg