Malegra DXT by Sunrise Remedies Pvt. Ltd

Malegra DXT is a combination of two chemicals- Sildenafil and Duloxetine. Sildenafil is used to treat erectile dysfunction while duloxetine helps in the treatment of premature ejaculation, both of which help improve the sexual life of a person. Although Malegra DXT is a prescription medicine, it can be bought from the online pharmacies without the need for any prescription. The drug can cause some serious side effects when taken with certain drugs, so it is necessary to consult a doctor before taking the medication. Malegra is available in the forms of oral capsules only. The company producing Malegra DXT is somewhat mediocre making the quality of Malegra DXT skeptical.

About Sunrise Remedies Pvt. Ltd

Malegra is made in India by Sunrise Remedies Private Limited. It is located in Ahmedabad, Gujarat. The company was first founded in 1995. Having an experience of 15 years, it has grown swiftly and introduced a lot of products in the local as well as the international market.

Sunrise Remedies Private Limited Main Office
Sunrise Remedies Private Limited Main Office

The company deals in Allopathic and Ayurvedic formulations as well as cosmetics. It claims to produce drugs of international standard and packaging. The company takes pride in one of its products i.e. “Jasebi cream” that is meant for relieving joint and back pain. It also proclaims to be an “expert manufacturer” of allopathic products relating to the treatment of ED. Additionally, it deals in antibiotics, analgesics, cough remedies and many more drugs. Although the company claims to be following the international standards and is compliant with the regulations of WHO and GMP, there is nothing solid available anywhere that support this claim. Hence, this manufacturer cannot be completely trusted. [1]

Scientific Studies on Malegra DXT

In a research named as “Sildenafil (Viagra) for male erectile dysfunction: a meta-analysis of clinical trial reports” conducted under the regulation of RA Moore, the researchers performed by the drug companies in the past during the licensing procedures were focused. This was carried out after statistically combining data from different clinical trials that would ultimately connect the dots to the formation of a new idea. For this meta-analysis to take place, information from various trials taking place since 1997 was used. The trials were carefully sorted and picked on the basis of their duration i.e. four weeks to a minimum. It involved all those trials whether dose dependent or independent. The result required from these trials was to successfully achieve an erection followed by penetration and proper sexual contact. For this trial, two groups were formed. One group, comprising of 2123 men, were given sildenafil citrate and the other group consisting of 1131 people were given a placebo. Instructions were to record and interpret efficacy and adverse effects and withdrawal among these people. It was recorded that in 49 percent of these men receiving sildenafil citrate, 60 percent of sexual advancements were successfully completed. About 30 percent of these men experienced side effects because of optimizing the doses of sildenafil citrate in them. Only a small fraction of 10 percent people discontinued the therapy. The conclusion drawn from this research was that these drug companies must make their clinical trial reports carried out privately for the purpose f getting a market approval for their drugs open for the public. This would serve as a source of information based on pure evidence and hence, might lead to the introduction of new technologies for a better future. [2]

Nazzareno Galiè, M.D. accomplished another research that was titled as “Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension”. This research was carried out to check how sildenafil citrate affected the patients suffering from hypertension. In this clinical trial, 278 people were included. Each of them was a patient of pulmonary hypertension irrespective of its origin e.g. idiopathic hypertension, hypertension due to shunts or any other cause. These patients were given different doses of sildenafil citrate, 20 mg drug given to 69 patients, 40 mg 68, and 80 mg to71 patients. Rest of the 70 people were given placebo treatment. The schedule of consuming sildenafil citrate orally for three times a day continued for twelve weeks. The main parameter of checking the effectiveness of sildenafil was based on the distance these patients could cover by walking on foot in six minutes. It further included checking an alteration in mean arterial pressure and checking for dyspnea on Borg Dyspnea Scale. The results were recorded at the end of the therapy. It was noticed that all of these patients receiving sildenafil citrate showed a marked decrease in their pulmonary hypertension. This was deduced by an increase seen in the distance covered by walking in six minutes by these patients. These people were also seen to be suffering from general side effects of sildenafil citrate i.e. flushing, diarrhea, and dyspepsia. Those who finished their therapy with sildenafil citrate for a year showed a great deal of improvement in the distance covered in six minutes i.e. 51m from baseline. [3]

Description and Mechanism of Action of Sildenafil citrate

Sildenafil citrate does not have any direct effect on the corpus cavernosum of the penis in males. It exerts its effects by maintaining a high concentration of Nitric oxide and cGMP in the penile tissue. This effect is achieved when sildenafil citrate binds to a PDE enzyme and prevents it from hydrolyzing cGMP to its inactive form. Consequently, cGMP is gathered in the spongy tissue in large amounts and is responsible for producing vasodilatation along with NO. The smooth muscles of the penis are relaxed allowing maximum blood to flow towards it. This assures a hard and long-standing erection in males. Hence, sildenafil citrate does not directly cause an increment in the quantity of vasodilator substance produced but allows it to withstand its breakdown for a longer period of time. [4]

Sildenafil citrate Effects

Malegra DXT has a dual function when it comes to the advantages of this drug. It not only makes sure that the person consuming it experiences a firm ejaculation but also restores the stamina after ejaculation for further advancement of the sexual activity. What is different about this drug is that it especially works to delay ejaculation and stop a premature one by the virtue of its secondary component- Duloxetine. [6] This effect is achieved by slowing down the neuronal movement from penis all the way to the brain. The erections are improved and the duration of sexual intercourse is increased, all this achieved without any decrease noticed in the sensitivity of the penis. It rapidly produces its effects and is equally useful in impotence related to almost all causes. It also causes an increase in libido. It as greater efficacy in treating ED as compared to other drugs because of the synergistic effect of both of its components. [5]

Recommended Doses and Duration of Therapy

Malegra DXT works best if taken 30-60 minutes before an anticipated sexual intercourse. It must be taken with lots of plain water for the drug to dissolve maximally in the bloodstream. It should not be taken right after consuming a fatty meal since it delays the onset of action of Malegra DXT. Light meals are preferred while the use of alcoholic beverages is discouraged. It is also advised to take one pill per day and not to exceed this set amount for overdosing may result in serious consequences. The effect of a single pill lasts for 4 hours. Therapy with Malegra DXT should continue as long as required or prescribed by the doctor. Malegra DXT is manufactured by Sunrise Remedies only in the form of tablets with two different formulations depending upon the potency of duloxetine in them. Malegra DXT 130mg are tablets containing 100 mg of sildenafil citrate and 30mg of duloxetine. Malegra DXT Plus contains 100mg sildenafil coupled with 60mg of duloxetine. [6]

Side effects and Warnings

Malegra DXT can cause a variety of side effects. This includes a general sense of dryness. The user might feel dryness, especially in his mouth and throat. A general feeling of sickness might prevail in some users. Its active ingredient i.e. Sildenafil citrate is commonly involved in causing gastrointestinal stress and diarrhea. In some cases, constipation overcomes the diarrheal effect of Malegra DXT. A headache and drowsiness are also experienced by some. Visual disturbances and changes in visual acuity is a rather serious side effect that is connected to the use of Malegra DXT. Patients must use this drug after consulting with a doctor first. It is contraindicated in pregnant women and people under 18 years of age. Also, those who are allergic to sildenafil or duloxetine must avoid its use. [5]

Drug Interactions

Malegra DXT is advised to be used after consulting with a physician. The reason behind this is the fact that Malegra DXT has an ability to cross-react with certain drugs if taken simultaneously and cause some serious complications. It is advised not to use an alpha blocker such as doxazosin while taking Malegra DXT. Patients undergoing a therapy for hypertension must also abstain from its use. Heart patients taking nitrates such as isosorbide or nitroprusside should particularly be careful about consuming Malegra DXT as the combination of both can lead to a serious fall in Bp and life-threatening hypotension. Azole antifungals like itraconazole are also contraindicated during therapy with Malegra DXT. Both bosentan and rifampin decrease the efficacy of Malegra if taken alongside it, hence, should not be used together. Additionally, this drug should not be paired up with other drugs used for the same purpose. [7]

Customer Reviews

Malegra DXT Customer Experience
Malegra DXT Customer Experience

Customer reviews about Malegra DXT are positive and supporting all the claims made by its manufacturer. Joshua in his review regarding this drug mentioned how Malegra DXT helped cure his ED problem and how he never thought he could get so much pleasure. Derek, another customer was satisfied with the results and confessed that the “results are tremendous”. In another feedback review, Todd shared how “this generic excellently helps” and recommended it to others.

Malegra DXT Consumer Reports
Malegra DXT Consumer Reports

Joshua Pierce reckoned Malegra DXT as “the best stuff” he has ever used and termed it even better than Viagra. Anthony shared that he chooses this drug because of the minimal side effects it brings with it. Mark O’ Brian told how Malegra DXT worked perfectly for him and how he was enjoying his “second youth”.

Price, Available Forms and Dosage

Malegra DXT Pricing
Malegra DXT Pricing

Malegra DXT can be bought at a price of $2.25 per pill from www.canada-pharmacy-24h.com. The total sum for ordering 20 pills hence becomes $44.96. If ordering pills more than 20, the price per pill reduces allowing customers to enjoy discounts.

Malegra DXT Shipping Options
Malegra DXT Shipping Options

On ordering medicines of worth more than $200, 10 percent discount can be availed. Shipment is delivered via regular AirMail service that cost $9.95 and take2-3 weeks to deliver. It is given as a complimentary service for orders above $200. Shipments can also be delivered by EMS which is charged at $19.95 and delivers within 3-8 days. It gets free of cost for orders above $300. Free pills are given with each order placed.

Malegra DXT in Shopping Cart
Malegra DXT in Shopping Cart

Delivery charges on www.rxtrustedmeds.com are $14.95 for AirMail delivery and $24.95 for delivery via EMS. An additional $6.95 is charged for delivery insurance. Free pills are given with every order placed. Tracking facility is available. Delivery is available all over the world including countries like the USA, Australia, and Canada. [8]

Conclusion and Rating

Malegra DXT is identical of Viagra with an addition of a secondary ingredient- duloxetine for dealing with premature ejaculation. The manufacturing company of this drug is not famous and there is nothing said with surety about its proved being FDA approved. Malegra DXT, hence, holds not a stable position in the market. Though the user reviews related to this drug are quite positive, I don’t think that it is holding its ground about the claim made in its name. Despite its availability in the online market, I found it to be rather infamous. Adverse effects related to Malegra DXT are minimal and mostly include those reported by any other ED drug like nausea, flushing, etc. Pricing of this drug is also economical. What bothered me about this drug is that it has everything in order and yet it has failed to emerge in the market as an effective drug for the treatment of erectile dysfunction. It can be because of lack of marketing or lack of effectiveness. Irrespective of whatever the reason for its failure is, it certainly is not a drug to use without consulting a physician first because of the ambiguities related to it. As far as rating is concerned, I am ambivalent about Malegra DXT so the drug gets 3 out of 5.

Malegra DXT Wiki Facts

  • Brand: Malegra DXT
  • Active Ingredient: Sildenafil Citrate and Duloxetine
  • Treatment: Erectile Dysfunction
  • Manufacturer: Sunrise Remedies Pvt. Ltd.
  • Country of Manufacture: India
  • Availability: USA, UK, EU, India.

Reference List

  1. Who we are [Internet]. Sunrise remedies. Available from: http://sunriseremedies.in/about-us.html
  2. Moore RA, Edwards JE, McQuay HJ. Sildenafil (Viagra) for male erectile dysfunction: a meta-analysis of clinical trial reports. BMC urology. 2002 May 22;2(1):1. Available from: http://bmcurol.biomedcentral.com/articles/10.1186/1471-2490-2-6
  3. Galiè N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D, Fleming T, Parpia T, Burgess G, Branzi A, Grimminger F. Sildenafil citrate therapy for pulmonary arterial hypertension. New England Journal of Medicine. 2005 Nov 17;353(20):2148-57. Available from: http://www.nejm.org/doi/full/10.1056/nejmoa050010#t=article
  4. The Biological Action of Sildenafil Citrate(Viagra™) [Internet]. Ch.ic. Available from: http://www.ch.ic.ac.uk/local/projects/s_llewellyn/Mechanism.htm
  5. How Malegra DXT Differs from Malegra FXT [Internet]. Malegra-FXT. Available from: http://www.malegra-fxt.com/malegra-fxt-vs-malegra-dxt.html
  6. Malegra – a Dependable Viagra Generic [Internet]. Malegra. Available from: http://malegra.biz/
  7. MALEGRA DXT INDICATIONS [Internet]. getmedsonline.org. Available from: http://getmedsonline.org/malegra-dxt/#.WEBnLtV94jd
  8. Malegra DXT [Internet]. rxtrustedmeds. Available from: http://rxtrustedmeds.com/product/Malegra DXT.html?q=malegra dxt

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