Combination treatments targeting both erectile dysfunction (ED) and premature ejaculation (PE) are also available in the market, but some brands have two options like Malegra DXT vs Malegra FST; is there any difference between Malegra DXT vs Malegra FXT? These are brands both from the same product line, Malegra, which is manufactured by the pharmaceutical company Sunrise Remedies which is located in India. Although these drugs contain both Sildenafil Citrate for erectile dysfunction, these medications also contain SSRIs (selective serotonin reuptake inhibitors) like Duloxetine and Fluoxetine, which are drugs indicated in the treatment of premature ejaculation in patients.

Malegra FXT 140 mg tablets
Malegra FXT 140 mg tablets


There are cases where erectile dysfunction and premature ejaculation are comorbid diseases in a single patient, although this disease comorbidity does not occur all the time. Often, it is either one or the other. But since these drugs are believed to give the patients a heightened sexual experience, most of the patients take combination drugs like Malegra FXT vs Malegra DXT even if they just have either conditions or even if they actually do not have either erectile dysfunction or premature ejaculation. Some users are able to get away with combination ED/PE treatments without having prescriptions for them because of lenient sellers on the internet. Although Malegra FXT vs Malegra DXT is also able to give the users a different sexual experience, using these products without a prescription and without the doctors’ advice is potentially dangerous.

Malegra DXT 130 mg Tablets
Malegra DXT 130 mg Tablets


Before discussing Malegra FXT and DXT versions, let us first define what are erectile dysfunction and premature ejaculation.

Erectile dysfunction (ED) is a condition where males are unable to have erections due to physiological and psychological factors. Even if there is adequate sexual stimulation and even if the patients want to, they are unable to have erections and maintain them. Age is one of the factors affecting the presence of the condition in patients. Age increases the risk of having erectile dysfunction; however, it is not the only factor affecting the condition’s progression in individuals. Age unrelated factors causing erectile dysfunction in patients are as follows:

  • Smoking, drinking, and drug abuse: these factors cause severe erectile dysfunction even in patients younger than 40.
  • Diabetes, heart disease, obesity, and prostate cancer: diseases such as these four contribute to the development of erectile dysfunction due to the tissue and organ damages they entail.
  • Stress, anxiety, depression, and other psychological illnesses: patients having these conditions are also affected in their response to sexual stimuli since the brain plays a great role in directing the erectile response.
  • Side effect of treatments: there are drugs taken by patients which are able to alter their reaction to sexual stimulation. Discontinuing the medications before they cause irreversible damage can reverse medication-side-effect-related ED cases patients.

Premature Ejaculation (PE), on the other hand, is a condition where an individual prematurely ejaculates with little sexual stimulation or penetration and before he wants to, which results in disappointment in both the patients and their partners. Most of the time, there is no clear cause of premature ejaculation in patients, but there are some factors determined to affect the incidence of PE in patients. Here are some possible factors affecting the incidence of PE in males:

  • Lack of practice: men usually learn to delay their orgasm with age. Young men with little experience usually are prone to PE.
  • Anxiety related to new partners: lack of confidence at times leads to PE in males.
  • Hormonal problems
  • Medication side effect
  • Lifestyle practices: smoking, alcoholism, and drug abuse are some of the factors affecting the condition.

How are ED and PE Diagnosed and Treated?

Erectile dysfunction and premature ejaculation are diagnosed by reviewing the sexual history of the patients and also by conducting a series of tests for erectile function and PE assessment. Patients are also assessed physically for diseases which may affect the prevalence of either PE or ED in patients.

Medical management is the common treatment for these two, if primary interventions like lifestyle modification, drug discontinuation, and others, fail. Erectile dysfunction and premature oftentimes occur separately, so patients are treated with separate medications for the diseases. Patients are given PDE5 inhibitors (Phosphodiesterase Type-5 inhibitors) like Sildenafil Citrate, Tadalafil, and Vardenafil for their erectile dysfunction, while patients with the condition premature ejaculation are given SSRIs (Selective Serotonin Reuptake Inhibitors) like Dapoxetine, Duloxetine, and Fluoxetine for delaying the ejaculation in patients.

PDE5 inhibitors are indicated for erectile dysfunction and are also approved for use in conditions such as pulmonary arterial hypertension (PAH) and benign prostatic hyperplasia (BPH); PDE5 inhibitors are FDA-approved treatments for the mentioned disease categories. PDE5 inhibitors block the PDE5 enzyme from degrading the cGMP (cyclic guanosine monophosphate) which is essential in eliciting the erectile response in patients

On the other hand, SSRIs are drugs which are primarily indicated for depression. SSRIs function by increasing the serotonin levels in the brain while not affecting the other neurotransmitters. The only FDA-approved SSRI for the treatment of PE is Dapoxetine and while Fluoxetine is also approved by the FDA for depression, it has not yet been approved by the FDA for the treatment of premature ejaculation.

Malegra FXT vs Malegra DXT

The competitors, Malegra FXT vs Malegra DXT are generic brands for the treatment of comorbid premature ejaculation and erectile dysfunction in patients. They have the same PDE5 inhibitor + SSRI component, but these two differ in the type of SSRI present on the drug. FXT refers to the drug’s Fluoxetine content, while DXT refers to the drug’s Dapoxetine content.

Available Doses and Intake

Malegra DXT (duloxetine) is available in 130 and 160 mg (100 mg Sildenafil + either 30 or 60 mg of Duloxetine) while Malegra FXT is available in 140 mg form (100 mg Sildenafil + 40 mg Fluoxetine). Like the regular PDE5 inhibitor drug, the patients should take either medication 30 minutes to 1 hour before sexual intercourse. Only a single dose of these meds is necessary for a day.

Side Effects

There are varied side effects which may be caused by each active ingredient of the medications. For their Sildenafil component, the patients may experience the following:

  • Headaches
  • Nausea
  • Vomiting
  • Blurred vision
  • Facial flushing
  • Dyspepsia
  • GI disturbance

For the Duloxetine component, users may expect the following side effects:

  • Dry mouth
  • Diarrhea or constipation
  • Feeling sick
  • Dizziness
  • Sleepiness
  • Malaise
  • Headaches
  • Blurred vision

As for Fluoxetine, here are some of the side effects which may be observed by the patients in their Fluoxetine use:

  • Nausea
  • Drowsiness
  • Dizziness
  • Tiredness
  • Appetite loss
  • Sweating
  • Insomnia
  • Anxiety

Both medications, Malegra DXT and Malegra FXT should only be taken under the supervision of the doctors since these drugs can cause serious adverse reactions when used for self-medication. Also, it is not advised for patients to use these combination drugs regularly because they might impair the ejaculatory response of the patients. While the as-needed use of these medications can help them delay the IELT (Intravaginal Ejaculatory Latency Time), the chronic use of SSRIs for delaying the ejaculatory function can cause patients to never ejaculate at all, as the chronic use of SSRIs is capable of altering the morphology of the male genital system. These are prescription meds which should be taken only when approved by the doctors to prevent permanent damage.


Reviews were available for Malegra DXT, but there are no reviews available for Malegra FXT or for Malegra DXT vs Malegra FXT function. The user reviews from the website were positive about the effect of Malegra DXT in the users

Malegra DXT Reviews from Users
Malegra DXT Reviews from Users

The users Richard Thompson and Charles Garcia are both recommending the use of Malegra DXT in buyers who are with comorbid ED and PE as they both mentioned that the drug worked well for their condition. But, they also said that buyers should consult their doctors first before taking this medication. Thomas Robinson is also happy about the drug’s effect and like Richard, he mentioned that he had been using the product for a long time (7 months during the time of his review). One the other hand, the buyer Joseph Martinez was pleased with the price of the product since according to him, the brand-name treatments for the conditions are expensive.


A number of online drugstores are able to sell both products, but we managed to look up the prices of both drugs in one vendor:

Malegra FXT 140 mg Prices
Malegra FXT 140 mg Prices


The prices of both drugs are identical; the store sells the products for $2.15 each for the minimum (20 tablets) purchase.

Malegra DXT 130 mg Prices
Malegra DXT 130 mg Prices

Of course, the store offers good deals for buyers who are willing to buy more items. If bought for 40 pieces, the price per pill significantly decreases to more than 50%; the tablet price goes down to $0.97 each.

So, which between Malegra FXT vs Malegra DXT is the Best?

We can’t really compare both drugs since there are insufficient reviews for FXT. The patients, however, loved the DXT version of the drug. Both drugs are actually recommendable; even though there is a battle between Malegra FXT vs Malegra DXT, both drugs are good generic options for ED/PE treatment in patients. They have good prices too. Buyers should use them with care since the drugs contain highly potent PDE5Is and SSRIs and should only take the drugs under the doctors’ advice.

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