Malegra is a generic form of Sildenafil citrate. Sildenafil Citrate is a medication used for the treatment of erectile dysfunction (ED) and is a prescription drug. Sildenafil is used by men who face difficulty in attaining an erection and also in maintaining it. Other drugs used for treating erectile dysfunction are Tadalafil and Vardenafil. The half-life of this drug is short and is taken as needed twenty minutes before sexual activity.

Two Types of Malegra

The only fact that makes Malegra different from other brands with the same generic such as Viagra is that it has formulated products that contain a second active ingredient which is either a SSRI (Selective Serotonin Reuptake inhibitor) or SNRI (Selective Serotonin and Norepinephrine Reuptake Inhibitor). The two types available for this product are Malegra DXT and Malegra FXT. Malegra DXT contains the combination of Sildenafil Citrate with Duloxetine, while Malegra FXT is a combination of Sildenafil Citrate with Fluoxetine. The combination of a Phosphodiesterase inhibitor with a SSRI or SNRI is helpful not only in the treatment of erectile dysfunction but also has an added benefit of treating premature ejaculation.

Actions of Malegra DXT and FXT

Both the product contains 100 milligrams of Sildenafil citrate which increases the blood flow to the penis and relaxes the smooth muscles of corpus cavernosum resulting in stronger erections. The other ingredient, Fluoxetine or Duloxetine help to stimulate the slowing down of neurons from the central nervous system, which helps in increasing the time of sexual intercourse by four to five times.

Malegra DXT Tablets
Malegra DXT Tablets

Malegra DXT has a double action because it contains Sildenafil citrate that helps increase the penile blood flow while Duloxetine helps to restore quickly after intercourse and give stronger erections again. Stimulation of the Central Nervous System also proves very helpful in increasing the patient’s quality of life.

Malegra FXT also gives erections and helps maintain it for a longer duration. Both the products are helpful in the treatment of erectile dysfunction as well as overcoming the problem of premature ejaculation.

The Difference Between Malegra DXT and FXT

The composition of the two drugs is the major difference between Malegra DXT and Malegra FXT. The secondary components of the medications are different in both the medications. Malegra DXT contains 30 milligrams of Duloxetine in combination with 100 milligrams of Sildenafil citrate, while Malegra FXT contains 40 milligrams of Fluoxetine combined with 100 milligrams of Sildenafil citrate. The mechanism of action of both the drug is similar, but they can differ in their impact. Due to the variation from person to person, and the fact that intolerance to a particular ingredient is possible, one drug can be used as an alternative to the other, depending on the patient’s tolerance. Duloxetine is also known to improve mood and sleep. It is also known to boost energy level and decrease the nervousness of the patient by restoring the natural balance of norepinephrine and serotonin in the brain.

Side Effects

The use of Sildenafil itself has many side effects that include bladder pain, numbness, tingling, burning in the chest, indigestion, upset stomach, and painful urination. Rare effects such as confusion, vision abnormalities, cold sweats, anxiety, changes in behavior, chills, blurred vision, pain in the chest, breast enlargement and tenderness, bone pain, dry eyes, dry mouth, excessive hunger, and fainting are also possible with Sildenafil use. There are some side effects of both the products. The side effects that can be observed with the use of Malegra DXT are a headache, vision changes, dizziness, and tiredness, and sleepiness, dryness of mouth, diarrhea, constipation, and feeling sick. The common side effects that are caused by the use of Malegra FXT are yawning, nausea, sweating, anxiety, tiredness, drowsiness, loss of appetite, dizziness, and sleep disorders.

With fluoxetine use the side effects that a patient can encounter are skin rashes, hives, pruritus, joint pain, muscle pain, chills, fever, convulsions, anxiety, difficulty in concentrating, paleness of skin, dryness of mouth, and headache. Other side effects such as behavioral changes, feeling unusually tired, incomplete facial and body movements, overactive reflexes of the patient, red or purple spots on the skin, walking unsteadily, breathing issues, blurred vision, cough, constipation, chest discomfort, pain in the eyes, depression, lightheadedness, and difficulty in swallowing have also been reported. In rare cases, reports of nosebleeds, nightmares, decreased bladder control, ankle or knee pain, abdominal pain, skin lesions, ulcers, pain in glands, thoughts of suicide, the stiffness of muscles, stopping of the heart, blood in vomit, bruising, and unpleasant or bad breath have been received.

Malegra FXT Tablets
Malegra FXT Tablets

When Duloxetine is used, the patient should know that some side effects are possible that include rashes, blistering of the skin, blurred vision, chills, sweating, confusion, fainting, lightheadedness, hives, muscle pain, weakness, irritation of the eyes, chest tightness, ulcers, swelling of the extremities, vomiting, yellow skin and eyes, and pain in the right side of the stomach. Minor side effects of Duloxetine are weight loss, sleep trouble, increased sweating, stuffy nose, runny nose, sore throat, muscle pain, sneezing, drowsiness, nausea, and loss of patient’s voice, lack of strength, congestion of the ear, frequent urination, appetite loss, and bowel movement difficulty.

In the case of Duloxetine overdose, symptoms of agitation, trembling, diarrhea, excitement, fever, bladder control loss, shivering, restlessness, lack of coordination, muscle spasms, and vomiting are experienced most commonly.


The drug shows significant incompatibilities with other medications that contain nitrates and other antihypertensive drugs. Concurrent treatment with such drugs can cause hypertensive emergencies which can be a very serious problem. In the case of hypersensitivity to any of the ingredients of these products, the treatment should be discontinued. For those patients who have a history of myocardial infarction, heart failure, arrhythmia, stroke, kidney disease or a blood disease, this line of treatment should not be considered. Malegra is effective in improving patient’s erections, but it does not show effects on the sperm count, hormones, or other functions.

Drug Interactions

Malegra interacts with organic nitrates, such as glyceryl trinitrate, Isosorbide Mononitrate, Isosorbide Mononitrate, and nitroglycerin. Other interactions of both forms of Malegra are those drugs also indicated for the treatment of impotence, home remedies to treat erectile dysfunction, bosantan, rifampicin, antihypertensive medications, alpha blockers, antifungal agents and antibiotics belonging to the class Macrolides such as erythromycin and clarithromycin.


Since Malegra is a generic form of Sildenafil citrate also known by the brand name of Viagra, it is a prescription drug and not intended for use by individuals who do not have a doctor’s prescription for its use. Patients who have impotence and erectile dysfunction are supposed to be given this medication, and the online drugstores that sell these products without requiring any prescription are at fault. In addition to the drug Sildenafil, the other two drugs are also not issued without a doctor’s order, and they have severe side effects if they are taken under conditions that might interact with these two drugs. Serious consequences such as thoughts of suicide and even death can occur if proper follow up I not done. The people operating online pharmacies should be educated enough so as to overcome any medication errors that might result in patient’s death. Taking into consideration the side effects of these drugs, when a person has erectile dysfunction, he should opt for other non-pharmacological treatments that are healthier and better for the patient’s quality of life. These treatments include weight loss, exercise, healthy diet, decreasing alcohol consumption, including fresh fruits and vegetables in their diet, improving sleep patterns, avoiding stress, and staying positive. Sometimes certain medications also induce impotence, and when they are discontinued (with a doctor’s order) or minimized in dose, the erectile dysfunction is reversed. If none of the above treatments work, your doctor will guide you with the best treatment according to your requirements and lifestyle; with calculated risk and benefit, a good treatment protocol is generated that is best suited to the patient.

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