Malegra Pro by Sunrise Remedies Pvt. Ltd.

Malegra Pro 100 is a generic drug marketed by Sunrise Remedies Pvt. Ltd. It has sildenafil citrate as the main active pharmaceutical ingredient. It is commonly prescribed for the management of Erectile Dysfunction (ED) in men. ED is a condition whereby men are unable to achieve a satisfactory erection. It is one of the most common diseases of sexual disorders which can be easily managed on an outpatient basis [1]. Malegra Pro 100 is a prescription only medication available in the strength doses of 50 and 100 mg. It has to be taken only after proper consultation with a doctor and, like all medications, has some adverse effects which can be minimized if certain precautions are taken. No doubt, the introduction of Sildenafil has revolutionized the treatment of ED, but over the years, different companies have released a myriad of generic brands and more data from clinical studies concerning Sildenafil have emerged. It is imperative to take all of this into consideration before choosing any particular brand of Sildenafil.

About Sunrise Remedies Pvt. Ltd

Sunrise Remedies Pvt. Ltd is a pharmaceutical company based in India. It was established in 1995 near Ahmadabad Gujarat and is involved in manufacturing and marketing of a myriad OTC and generic medications along with healthcare and ayurvedic products. According to its website, the company has been constantly expanding for the last 16 years and striving to achieve WHO-GMP standards and quality in all its products. However, whether their products are approved by the USA-FDA or any other internationally recognized institution could not be verified.

Sunrise Remedies Pvt. Ltd Location
Sunrise Remedies Pvt. Ltd Location

Sunrise Remedies Pvt. Ltd manufactures various generic versions of Sildenafil, tadalafil, vardenafil and Dapoxetine of different strengths and doses. It is difficult to assess the credibility of Sunrise Remedies Pvt. Ltd. compared to other pharmaceutical giants based in India; it is a young company still striving to get a niche. Furthermore, without any proper accreditation and achievements to showcase, it is unwise to blindly trust its products. Its R&D facility is still awaiting WHO-GMP certification [2].

Scientific Research on Sildenafil Citrate

Since its advent in 1998, Sildenafil citrate has revolutionized the treatment of ED. Various studies have been carried out to establish its safety, potency, long-term efficacy and side effects. In 2009, M.Fujisawa et Al conducted a study titled “clinical efficacy and safety of sildenafil in elderly patients with erectile dysfunction”a href=”#reference_1″>[1]. 44 elderly men suffering from ED were included in the study. They were treated with Sildenafil and followed up for up to 25 months. Improvements in symptoms were documented through the International Index of Erectile Function (IIEF) which increased from an average of 8.5 to 20. Oral Sildenafil was hence considered efficacious in the treatment of ED. In 2002, Fink HA et Al carried out “Sildenafil for male erectile dysfunction: a systematic review and meta-analysis”. Various trials and data were analyzed and 27 trials with more than 6600 men were included. After a detailed review and analysis, it was concluded that sildenafil does improve erectile function. It is tolerated quite well and the side effects do not warrant discontinuation. The meta-analysis also concluded that the most common side effect reported was a headache and flushing. [3]

The Feb 2010 issue of the American Family Physician (AFP) contained the article “Management of Erectile Dysfunction”. Apart from the etiology, pathogenesis and general management of ED, it also discussed the PDE5 inhibitors. According to AFP, Sildenafil shows a significant improvement in erections when compared to the placebo effect. Also, Sildenafil does not affect libido in any way. AFP also states that all PDE 5 are equal in efficiency though they might differ in duration or onset [4]. The American Urological Association (AUA) also has certain guidelines pertaining to ED. According to their 1996 evidence-based report “Report on the Treatment of Organic Erectile Dysfunction”, treatment of ED includes a first line therapy with PDE5 inhibitors like Sildenafil. Based on reviews of at least 112 randomized trials and the AUA a panel, PDE5 are a standard in the treatment of ED [5]. It can be used and has shown a good response even in very elderly patients along with those who have some other co-morbid conditions like Diabetes, ischemic heart disease (with caution) and are on SSRIs. Whatever be the cause of ED, PDE5 inhibitors like Sildenafil are the first line of therapy offered to the patients. The data from all trials, studies, and clinical observation do suggest that if used properly, Sildenafil citrate is very effective in keeping the symptoms of ED at bay. The negative impact that impotence has on mental health can be prevented.

How Sildenafil Citrate Works

Sildenafil citrate causes the inhibition of the enzyme phosphodiesterase type 5 (PDE5). In the erectile tissues of the penis, there is increased blood flow secondary to the release of cGMP and nitric oxide during sexual stimulation. This increased flow causes erection of the penile tissues. It is CGMP and nitric oxide that maintains the vasodilatation of the blood vessels, therefore, by inhibiting PDE5, cGMP remains longer in the blood and causes prolonged erection. [6]

Effects of Sildenafil Citrate

By relaxing the smooth muscles of blood vessels and maintaining blood flow to the penis, sildenafil ensures continued erection for a satisfactory sexual intercourse. It hence has a beneficial effect on men suffering from ED. For sildenafil to be effective, sexual arousal is necessary. Taking Sildenafil, at least 1 hour prior to any sexual activity, men with ED are able to maintain an erection. However, Sildenafil is a temporary treatment for ED, not a permanent cure.

Recommended Doses and Duration of Therapy

Depending on the circumstances, the daily dose of Malegra Pro can range from 25 mg to 100 mg. In cases of kidney and liver impairment or age more than 65 years, it is better to start with 25 mg after consultation with a doctor. Otherwise, a starting dose of 50 -100 mg is acceptable. The maximum dose that should not be exceeded in 24 hours is 100mg [4].

It is to be noted that Sildenafil is used to control the symptoms of ED; it is not a cure. The duration of therapy is, therefore, depending on the patient’s discretion or development of side effects warranting discontinuation.

Side effects and Warnings

No drug is free from side effects. In the case of Sildenafil citrate, most side effects are secondary to vasodilatation in other organs of the body. The most frequently reported symptom is a headache followed by flushing of face and neck, dizziness, bleeding from nose, diarrhea and blurred vision. Fortunately, tolerance develops to most side effects with continued usage of the drug. Conversely, side effects which warrant urgent medical attention are chest pain, erection for more than 4 hours or sudden loss of vision [4].

Patients who have liver, heart or kidney diseases should take Malegra Pro only after seeking proper medical opinion. Finally, those with anatomical deformity of the penis like Peyronie’s Disease should altogether avoid Malegra Pro.

Drug Interactions

It is strictly prohibited to consume Sildenafil along with other vasodilating agents, especially Nitrates like amyl nitrate and nitroglycerin. The synergistic effect of both drugs can cause dangerous and potentially fatal hypotension. Furthermore, people on antiviral therapy with protease inhibitors should also lower their usual dose of Malegra Pro. This is because protease inhibitors prolong the effect of Sildenafil in the body [7].

Customer Reviews

Compared to other generic brands of Sildenafil, reviews concerning Malagra Pro were scarce in numbers and quite polarized. One user shared his opinion that Malegra is not very good and contains lots of undisclosed chemical components. He has tested other generic brands of Sildenafil though, not Malegra Pro. Another user states that he “never tried it, but would like to.” However, from his comments, it seems he confused Sildenafil with Dapoxetine.

Malegra Pro Consumer Reports
Malegra Pro Consumer Reports

Conversely, on another site, James Burkhead is happy with effects of Malegra Pro. He was looking for an alternative to Viagra and ordered Malegra Pro. He finds it “quite affordable and incredible medicine!” Similarly, Carter Collins also thinks that choosing Malagra Pro was the best decision and its rates are reasonable.

Malegra Pro Customer Experience
Malegra Pro Customer Experience

The reviews about Malegra Pro are few and polarized. It is hence difficult to judge its true potential. It is highly possible that the positive opinions given by the users are fabricated and placed by the manufacturers to boost the image. It is recommended to get Malegra Pro only after ensuring it worked for actual customers.

Price, Available Forms and Dosage

According to the site Amigosdoamor.com, 1 pill of Malegra Pro is sold for $3.00. However, if bought in larger quantities, the price is discounted to $2.25 and free shipping can be taken advantage of. [8].

Malegra Pro Pricing
Malegra Pro Pricing

On other online pharmacies, the price per pill is as low as $0.5- $1.00 with a flat shipping fee of $16.00. Most websites provide options for worldwide shipping to most countries including USA, UK, Australia and Canada along with airmail services as well.

Malegra Pro in Shopping Cart
Malegra Pro in Shopping Cart

Malegra Pro is available in a tablet form of 50/100 mg strength. The recommended dose is 50-100 mg depending on response.

Conclusion and Rating

Malegra Pro 100 is a generic sildenafil available locally in India and sold internationally on online pharmacies to countries like USA and UK. It is marketed by Sunrise Remedies Pvt Ltd, a pharmaceutical company in India. Deeper analysis of the availability, safety, and potency of Malegra Pro allows certain things to be exposed. Firstly, the credibility of the manufacturer could not be verified. I am not even sure if it meets WHO-GMP specification during manufacturing or no. No other accreditation could be verified. Compared to other well-established pharmaceutical institutes in India, Sunrise Remedies Pvt Ltd is quite new. Secondly, customer reviews concerning Malegra Pro were few and contradictory. Few recommend it while others are wary of it. In such cases, it becomes difficult to gauge the true efficacy of a drug. Sildenafil, the main ingredient of this brand, is a well-researched substance with well-established parameters of safety, potency, efficacy and toxicity. However, Malegra Pro is a generic product and hence will have other unidentified constituents. It is quite cheap product, but health is much more important than saving a few dollars. I give Malegra a rating of 2 out of 5 stars and recommend to choose another alternative if possible and go for Malegra only if no other options are available.

Malegra Pro 100 Wiki Facts

  • Brand: Malegra Pro 100
  • Active Ingredient: Sildenafil Citrate
  • Treatment: Erectile Dysfunction
  • Manufacturer: Sunrise Remedies Pvt. Ltd.
  • Country of Manufacture: India
  • Availability: USA, UK, India, EU

Reference List

  1. Fujisawa M, Sawada K. Clinical efficacy and safety of sildenafil in elderly patients with erectile dysfunction. Archives of andrology. 2004 Jan 1;50(4):255-60. http://www.tandfonline.com/doi/abs/10.1080/01485010490448589
  2. About Sunrise Remedies- Sunrise Remedies Pvt Ltd- last updated 2015- Retrieved: http://sunriseremedies.in/about-us.html
  3. Fink HA, Mac Donald R, Rutks IR, Nelson DB, Wilt TJ. Sildenafil for male erectile dysfunction: a systematic review and meta-analysis. Archives of Internal Medicine. 2002 Jun 24;162(12):1349-60. http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/211714
  4. Management of Erectile Dysfunction-JOEL J. HEIDELBAUGH, MD, University of Michigan, Ann Arbor, Michigan Am Fam Physician. 2010 Feb 1;81(3):305-312. http://www.aafp.org/afp/2010/0201/p305.html
  5. AUA Guideline on the Management of Erectile Dysfunction: Diagnosis and Treatment Recommendations- The American Urological Association- (published 2005)- Retrieved: https://www.auanet.org/education/guidelines/erectile-dysfunction.cfm
  6. Gareri P, Castagna A, Francomano D, Cerminara G, De Fazio P. Erectile dysfunction in the elderly: an old widespread issue with novel treatment perspectives. International journal of endocrinology. 2014 Mar 17;2014. http://dx.doi.org/10.1155/2014/878670
  7. Chinello P, Cicalini S, Pichini S, Pacifici R, Tempestilli M, Petrosillo N. Sildenafil plasma concentrations in two HIV patients with pulmonary hypertension treated with ritonavir-boosted protease inhibitors. Current HIV research. 2012 Mar 1;10(2):162-4. https://www.ncbi.nlm.nih.gov/pubmed/22329523
  8. Malegra Pro 100 mg Sildenafil Citrate- Amogosdoamor.com- Retrieved: http://amigosdoamor.com/malegra-pro-100-sildenafil-citrate-100mg

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