Malegra 100 is one of the generic ED meds available in the market which has SC as an API. The product contains 100 mg of SC per pill and is indicated mostly for patients with ED. For some, it is a good option for ED treatment as it has the same API (SC), plus it is more affordable than the brand-name treatment available.

According to the study by Park, Hwang, and Kim (2011), “Prevalence and medical management of erectile dysfunction in Asia”, Erectile Dysfunction (ED) in men is a globally prevalent issue that needs to be addressed, as it is affecting not only the physiological aspect of the patients, but it also affects their quality of life (and their partners), and also influences them psychosocially [1]. The study discovered that the prevalence rate in Asia alone for ED is between 2%-88% and also determined that ED is a prevalent health concern for the mentioned region, but the patients affected by the disease are prevented by a number of sociocultural and economic factors from seeking the appropriate treatment [1]. This may also be associated with the exorbitant pricing of the brand-name treatments available for the patients.

It was for this reason that the existence of branded generics came to be. A number of companies started producing generics with the same Sildenafil Citrate (SC) active pharmaceutical ingredient (API). These companies also were able to sell the products for a fraction of the brand-name medication’s prices, as some pharmacies sell them for less than $2 each pill [2]. Sunrise Remedies Pvt. Ltd. is one of the manufacturing companies which made generic counterparts for the brand-name meds.

Sunrise Remedies Pvt. Ltd. Profile

Unlike most of the pharmaceutical companies whose focus is only on the manufacture of generic medications, Sunrise Remedies include the manufacture of Herbal Remedies, Cosmetics, and Ayurvedic medications which are related to traditional Indian medicine [3]. Sunrise Remedies started in 1995 and according to its company information, it is one of the fastest-growing pharmaceutical corporations [3].

Sunrise Remedies Pvt. Ltd. Main Office
Sunrise Remedies Pvt. Ltd. Main Office

There was not much mention regarding its US FDA approvals (which is technically important to any generic medication manufacturer), but there was a mention that the company is making its products according to WHO-GMP standards [3], albeit there was no indication that its manufacturing process is WHO-GMP compliant (accredited). The company’s info cited though that it makes allopathic formulations like ED meds in tablet, capsule, liquid, and topical forms based on “international acceptable levels” [3].

Aside from being the maker of the Malegra product line, Sunrise Remedies manufactures other products for ED with Tadalafil, Vardenafil, Avanafil, Udenafil, and Dapoxetine [4]. Aside from those products, the company is also well-known in India for its JESIBI cream meant for back and joint pain [3].

Studies Made on Sildenafil Citrate

Although Sildenafil Citrate (SC) is an effective agent in improving the sexual response of the patients, it still remains only a treatment for Erectile Dysfunction (ED), and not really a cure (“Long-term safety and effectiveness of sildenafil citrate in men with erectile dysfunction” by McMurray [5]. Since this is the case, according to the study [5], men afflicted with ED decide to take SC medication for extended periods to maintain their sexual response. The study [5] aimed to determine the possible outcomes of using SC for ED for extended periods, in this case, in a 4-year, open-label, extension study. Of the initial 979 participants of the study (mean age 58 years), only 584 of them were able to complete the 4-year duration. A number of the participants discontinued treatment due to their loss of interest, insufficient clinical response (3%, and only 62 out of the 979), loss of partner, loss of follow-up, and ability to purchase the SC drug by themselves, and adverse events (37 patients, 3.8% of the participants) [5]. As checked yearly, the patients responded well to SC treatment and only a small fraction did experience adverse events and insufficient clinical response which led to the discontinuation of the SC treatment for ED. All in all, long-term therapy using SC for ED seemed viable, as there was no exhibited drug tolerance and only a few did not respond well to treatment (3%) and experienced adverse events (3.8%) [5].

Since there is little question in the effectiveness of SC treatments for ED even in long-term therapies, SC remains to be one of the highly recommended and most used treatments for ED prevalent in the male population. But, SC seems to have more potential than being just an ED treatment. There are a number of studies utilizing the said API for other purposes than a male drug. Research also explored the use of SC for primary dysmenorrhea in females. One research, “Sildenafil citrate in the treatment of pain in primary dysmenorrhea: a randomized controlled trial†” by Dmitrovic, Kunselman, and Legro (2013), studied if the vaginal preparation using SC is effective in dysmenorrhea treatment [6]. The researchers have explored this possibility since NO (nitric oxide) oral preparations were widely used as myometrial cell relaxants as they have the capability to reverse prostaglandin-induced vasoconstriction and relieve pain [6]. Since it is well-known that SC has the ability to function as a PDE5i (phosphodiesterase type 5 inhibitor) by augmenting NO’s vasodilatory effect, the researchers made a vaginal prep containing SC to see if it will function as a dysmenorrhea pain treatment too. The study concluded that SC vaginal preparation with 100 mg SC as API is also viable as a dysmenorrhea-pain reliever by relaxing the myometrial cells, but with no side effects as compared to other NO oral preparations. SC also helped in improving the endometrial blood flow in participants [6].

Since SC’s effect influences the male sexual response, research in the past few years also has taken into consideration its effect on the female sexual response since they were similar. One such study, “Women taking the “blue pill” (sildenafil citrate): such a big deal?” by Monte reviewed whether SC is effective in improving the female sexual response [7]. However, the results were conflicting regarding its benefits as there were noted adverse effects linked to the use of SC for the female sexual response [7]. Since female sexual arousal disorder (FSAD) seems to be a complex case, SC is not determined as a primary option for treating the condition, as concluded by the research [7].

Mechanism of Action of Sildenafil Citrate

Sildenafil Citrate (SC) works primarily as a PDE5i which has a direct action of inhibiting the neurotransmitter so that the cGMP produced upon sexual stimulation may not be eliminated just yet. cGMP is the one responsible for the erectile response, as its presence promotes vasodilation and smooth muscle relaxation so that blood flow is increased in the penile tissue. SC inhibits PDE5 from disintegrating the cGMP present [6], therefore erection is maintained. The action of SC as an API can last up to an average of 4 hours. But even if SC promotes erectile response, sexual stimulation is still required.

Effects of Sildenafil Citrate

Since the clinical action of SC on the host (as a PDE5i and an augmenting agent for cGMP) is determined, patients should expect that SC-containing medication will help improve their erectile response. As the internet pharmacies put it, SC meds can “boost the sexual wellness” of the users [8]. SC drugs work as an enhancer of the erectile response and do not cause spontaneous erections without the presence of any sexual stimuli, so users have to be stimulated first before the drug can take effect.

Recommended Doses and Duration of Therapy

The typically prescribed initial dose for Sildenafil-containing medication is 50 mg, but it may be increased to 100 mg depending on the response of the patient; it may also be decreased to 25 mg depending on SC’s effectiveness and patient tolerance [1]. It is also advised that the patients should take SC medication 1 hour before the intended sexual activity [1]. Because SC is not an intended cure for ED, but only a treatment for ED [5], it does not have a recommended length of therapy. SC treatment, though, is being considered to be implemented for long-term, as clinical trials for long-term use for SC-containing drugs prove promising [5].

Side effects and warnings

In a study conducted for determining the long-term effects of SC in patients [5], there were reported side effects for the drug, although they were not quite prevalent in the tested population, and accounted for only 3.8% of the 979 participants [5]. The most common side effects brought about by SC in patients were headache and dyspepsia. Other side effects noted on patients under SC mediation are rhinitis, flushing, abnormal vision, dizziness, mild palpitations, moderate tachycardia, conjunctivitis, and photophobia [5], although these reported side effects were not prevalent.

Drug interactions

Sildenafil Citrate pills should never be taken in conjunction with other ED medication, so Malegra 100 is also contraindicated to be taken with other ED meds [8]. It is highly contraindicated for ED meds to be taken along with other ED meds since the interaction among these meds may exacerbate the side effects [8]. Other drugs contraindicated to SC meds are nitrates, antibiotics, HIV meds, blood pressure medication, and antifungal medications [8].

Customer Reviews

Not many reviews are available online for Malegra, but those found for the drug were all commending the drug’s action for ED. It is well-expected though that Malegra 100 would give the users improved erectile function since SC’s effect as a potent inhibitor for PDE5 is established. Reviewers for Malegra 100 were positive on the drug’s potency and even noted that the drug gave them good value for their cash.

Malegra 100 Testimonial
Malegra 100 Testimonial

The product is recommendable, but more reviews should be found for the drug. So far, based on the client comments, Malegra is potent and may be another option for SC medication for ED patients.

Price, Available Forms and Dosage

Malegra 100 Prices
Malegra 100 Prices

Product pricing for Malegra 100 varies from one site to another. But it is commonly sold cheaper than the famous brand-name SC drug for ED. sell the product from $0.76 to $1.80 per pill depending on the quantity to be purchased—the more pills bought, the higher the discount.

Malegra 100 Pricing
Malegra 100 Pricing

On the other hand, sells Malegra 100 for $48 to $60 for a batch of 30 pills. Internet pharmacies usually sell generic medication for less, so ED pill users usually turn to internet pharmacies for the purchase of ED medication.

Malegra 100 Shipping Methods
Malegra 100 Shipping Methods

With regards to shipping, the online drugstores charge per delivery method. The stores mentioned above may ship the products to the USA, Australia and Canada (and other locations) for free via Airmail, but for a minimum order amount. Shipping fee shown for the online pharmacies take about $22 for EMS (or the faster delivery). Some shops offer two shipping options (Airmail and EMS), but in this case, the shops offered only EMS shipping for the buyers.

Conclusion and Rating

ED is a prevalent condition that patients may or may not be aware of. A study conducted in Asian men showed the prevalence of ED in the region is about 80%, but the patients have limited options when it comes to treatment, and a number of factors are affecting these patients’ ability to undergo the proper treatment. For some, though, the reason for not undergoing treatment is mainly the cost of the medication, as the well-known product for ED still costs too high.

Due to that fact, a large number of pharmaceutical companies obtained the rights to make generic drug versions containing Sildenafil Citrate. Since they did not have to pay for years of research and a number of excess costs, the companies like Sunrise Remedies were able to ask for less from the buyers for their products. Malegra products are Sunrise Remedies’ version of SC medication, and the company has s number of variations for the product. In this review, though, the only presented product for Malegra was the 100 mg “regular/hard” pill.

Malegra 100 is expected to work similarly to is brand-name analog since it contains the same amount of API in it. Reviews, though few, reflected the users’ satisfaction with the product and it is notable that they were well-pleased. As for the rating, although Malegra 100 pills are actually well-received by the Internet drug buyers and was manufactured by a prominent company in India, I can only rate the product 3 out of 5, as there is not much information on the quality control and the standing of Sunrise Remedies in terms of US FDA/WHO-GMP compliance. But even if that’s the case, I think the product can still be recommended, as there were no reports of adverse reactions from the user population (yet, anyway).

Malegra 100 Wiki Facts

  • Brand:Malegra 100
  • Active Ingredient: Sildenafil Citrate
  • Treatment: Erectile Dysfunction
  • Manufacturer: Sunrise Remedies Pvt. Ltd.
  • Country of Manufacture: India
  • Availability: India, USA, UK, EU, Australia, ++

Reference List

  1. Park K, Hwang EC, Kim SO. Prevalence and medical management of erectile dysfunction in Asia. Asian J Androl. 2011 Jul; 13(4): 543–549. Available from:
  2. Malegra 100 mg Tablets. Available from:
  3. Welcome To Sunrise Remedies. Available from:
  4. MAN PRODUCTS. Available from:
  5. McMurray JG, Feldman RA, Auerbach SM, DeRiesthal H, Wilson N, On behalf of the Multicenter Study Group. Long-term safety and effectiveness of sildenafil citrate in men with erectile dysfunction. Ther Clin Risk Manag. 2007 Dec; 3(6): 975–981. Available from:
  6. Dmitrovic R, Kunselman AR, Legro RS. Sildenafil citrate in the treatment of pain in primary dysmenorrhea: a randomized controlled trial†. Hum Reprod. 2013 Nov; 28(11): 2958–2965. Available from:
  7. Monte GL, Graziano A, Piva I, Marci R. Women taking the “blue pill”(sildenafil citrate): such a big deal?. Drug design, development and therapy. 2014;8:2251. Available from:
  8. Malegra (Sildenafil Citrate). Available from:

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